Losartan | how long until it works and how long does it stay in the system

High Blood Pressure Medication

How long does it take losartan to work?  How long does losartan stay in the system?

Losartan is a medication used to lower blood pressure. It is from a class of medicines known as ARBs. Angiotensin-receptor blockers (ARBs) treat high blood pressure by causing blood vessels to relax.  They may have an effect on electrolytes like sodium and potassium and your health care provider will monitor your electrolytes with labs.

It starts working within 6 hours of taking the medication by mouth. It must be taken daily for the blood pressure to adequately controlled. And, it could be up to a month until the full effect of the medication is realized. It is important to take it every day to maintain lower blood pressure.losartan-in-the-system-and-when-it-works

The losartan in the system does not last long.  The liver converts it to a more powerful medicine.  The more powerful form of losartan has a half life of 6 to 9 hours.  That means every 6 to 9 hours half of the medicine is removed from the body.  However, enough of the medicine stays in the system to provide blood lower effects for 24 hours. Those with impaired livers may need lower doses.

If you don’t feel your medication is not working properly or you feel you may be experiencing side effects, be sure to contact your doctor or pharmacist. Never make changes to your medications or diet without first speaking to your healthcare provider.

Thank you for visiting my website, I hope you found the information useful.  Please feel free to contact me with any pharmacy or medication related questions.

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The pharmaceutical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education and should not be used as a substitute for professional diagnosis and treatment.
5 comments… add one
  • Lori Link

    This is a poorly written sentence in your article above:
    “If you don’t feel your medication is not working properly”

    Might want to clarify what you mean. I assume it was to be “If you don’t feel your medication is working properly”…

  • George Mumbuna Link

    I want you to be sending me newsletter

  • Steve Bushemi Link

    Sorry 4 hours not 64

  • Steve Bushemi Link

    64 hours after taking my first dose. My pressure had not changed. 150/105/63 i was worried and took 0.1 clonidine. Should I be concerned?

  • Tom Kalinke Link

    This was very helpful. I was wondering why it was taking 4 hours to see my BP drop (on a 25 mg dose), and why I was back to my old non-medicated BP by the 24 hour mark. I raised the same questions with my doctor but haven’t gotten a reply yet.

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