Can Nexium [esomeprazole] and ranitidine [Zantac] be used together in the same day?
Nexium (and the generic esomeprazole) is a medication known as a proton pump inhibitor (PPI). It suppresses stomach acid by preventing the parietal cell from producing acid. The most common side effects include headache, diarrhea and nausea. Long-term use may lead to Vitamin B12 deficiency. PPIs are considered to be stronger at reducing stomach acid than H2 blockers.
Ranitidine (and the brand name Zantac) is an H2 blocker. It is an acid suppresser. It blocks the Histamine 2 receptor, that in turn reduces the amount of acid produced for the stomach. It is usually used to treat or prevent heart burn and ulcers. Long-term may also lead to a Vitamin B12 deficiency.
There is no major drug interaction between Nexium and ranitidine. They can be used together to control GERD, reflux, heart burn or prevent stomach damage from other medications. If the condition is serious enough to require two medications, a doctor should be monitoring the patient.
If your healthcare provider recommends the use of both Nexium and Ranitidine, they can be taken together. However, the doses are typically separated. You could take Nexium in the morning and Zantac at night. Again, remember that stomach acid medications may cause certain vitamin and mineral absorption problems. Long-term should be avoided if possible. Also be certain to discuss the use of over-the-counter medications with your doctor.