Hydroxyzine and Loratadine

Drug Interactions

Can I use hydroxyzine and loratadine together?

Loratadine is a a second generation antihistamine or allergy medication. It blocks the action of histamine in the body at the H1 receptor. It is use to treat and prevent allergy symptoms. Common side effects can include drowsiness, headache, dry mouth and diarrhea. It is sold in the United States under the brand name Claritin and Alavert. The typical adult dose is 10mg once a day.

hydroxyzine and loratadine


Hydroxyzine HCl is a first generation antihistamine and is used to treat allergies, anxiety and difficulty sleeping. It is sometimes referred to by the brand names Atarax or Vistaril.  Not only does is help with allergy symptoms, it also has a sedating effect. It can effectively treat allergy symptoms when there is itching involved. Side effects can include dry mouth, drowsiness, dizziness, impaired speaking ability, nausea and headache. Typical adult doses range from 25mg to 100mg given every four to six hours as needed to control symptoms.

Vistaril [hydroxyzine] and Claritin [loratadine] Together

There is not a major interaction between the two medications that has been identified. However, using hydroxyzine and loratadine together can increase the risk of side effects. Both medications have similar side effects, as they act on the same receptors in the body. If a person used both Atarax and Claritin together at the same time they most likely would experience sedation and dry mouth. Other side effects may occur. And, adverse reactions can happen with any medication.

It is always best to speak with your doctor or pharmacist if you are uncertain about using medications together. Also, let them know if you have every had any adverse reactions to mediations.

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The pharmaceutical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education and should not be used as a substitute for professional diagnosis and treatment.
2 comments… add one
  • Will Link

    I have been taking both for a couple of years now, and it is my understanding that Loratadine is a modified form of Hydroxizine that doesn’t cross the blood-brain barrier, hence no drowsiness or other Central Nervous System side effects. I take both because I am very sensitive to the Hydroxizine, but Loratadine is not enough on it’s own. The combination allows me to get by with only 20mg of Hydroxizine a day.

  • Arlene Mielczarski Link

    My doctor gave me lorontine (which is perscriptive for claritin). I am afraid to take it as I take 50 mg of Hydrozzine at night before I go to sleep with anxiety. I have been having allergies and a sore throat for 2 months. I took antibiotics, but still a sore throat and hurts when I swallow food. I don’t want heart palpitations from taking the two. He told me to take the lorontine in the morning and the hydrozzine at bedtime. I don’t want to have any interactions or problem trying to sleep. It is 10 mg of the lorontine. Do you see any problems with taking the lorontine in the morning and the 50mg hydrozzine at night?

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