Allopurinol and HCTZ (hydrochlorothiazide)

Drug Interactions

allopurinol and hctz


Is there an interaction between hydrochlorothiazide [hctz] and allopurinol?

HCTZ or hydrochlorothiazide is water pill or more specifically a thiazide diuretic. It is typically used to reduce blood pressure and manage fluid retention. Common side effects can include low blood pressure, dizziness, low potassium and increased sensitivity to light.

Allopurinol is a Xanthine Oxidase Inhibitor. It is most commonly use to prevent gout by reducing the amount of uric acid produced in the body. It may also be used to prevent kidney stones and used with certain types of cancer treatments. The most common side effects include rash, nausea and diarrhea. Contact your doctor immediately if you develop a rash, as it could indicate a serious side effect.

Taking HCTZ and allopurinol can increase the chance of an allergy to allopurinol. It is typically not advised to use the two medications together. Your doctor may determine it is in your best interest to use both and then they would most likely be give at low doses. If you doctor wants you on both be sure to monitor closely for side effects.

Side effects and interactions can happen to anyone. Always contact a healthcare provider if you are having problems with medications or you are uncertain about which medications it is safe to take together.

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