What is the interaction between allopurinol and azathioprine?
Allopurinol is a Xanthine Oxidase Inhibitor. It is use to prevent gout and prevent certain types of kidney stone. It also use with some types of cancer treatments. The most common side effects include rash, diarrhea and nausea. Please contact your healthcare provider if a rash develops.
Azathioprine (and the brand name Imuran) is used to suppress the immune system. It is generally used to prevent kidney transplant rejection or for rheumatoid arthritis. It may also be use for other conditions (current research includes crohn’s, ulcerative colitis and IBD). The most common side effects include infection, nausea, diarrhea and reduction in certain types of blood cells.
It is recommend that allopurinol and azathioprine not be used together. Allopurinol can cause an increase of azathioprine in the body. That dramatically increases the risk of side effects. If you doctor determines it is in your best interest to use both medications, the dose of azathioprine with be lowered and you will be closely monitored for side effects.
Always watch for side effects and interactions with medications. Please contact a healthcare provider if you feel you are experiencing side effects or drug interaction.
