Loratadine and Benadryl

allergy medication
using loratadine and benadryl together


Can I take loratadine and Benadryl together at the same time? Is ok to use them in the same day?

Loratadine is a newer non drowsy antihistamine. It is sold as the brand name Claritin. It is usually take once per day to reduce allergy symptoms.  The most common side effect is headache and on rare occasions it can cause drowsiness.

Benadryl (and the generic diphenhydramine) is a stronger antihistamine. Although it is stronger, it also tends to make people very drowsy.  Other common side effects include: difficulty urinating, slowed reaction time, headache, constipation, low blood pressure, blurred vision and racing heart.

There is no specific drug interaction between loratadine and Benadryl, however using the two will definitely increase the chance of side effects. There are things one could to to reduce the chance of increased side effects like take the Claritin in the morning and the Benadryl at night or try to take the Claritin and Benadryl 12 hours apart. Most people are fine taking a Claritin early in the day and the a Benadryl later. Extreme caution should be used especially if you have to drive or complete tasks that require heightened alertness.  The sedation from the diphenhydramine can be significant and some people even experience reduced mental clarity. For strong allergic reactions like hives, one may need to take two medications.

Always chat with your doctor or pharmacist if you are unsure which medications you can use together. A minute or two to clear up any uncertainty can reduce the chance you’ll have side effects.

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The pharmaceutical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education and should not be used as a substitute for professional diagnosis and treatment.
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