Can you take gabapentin and ranitidine [Zantac] together at the same time?
Gabapentin (and the brand name Neurontin) is a medication originally intended to treat seizures. However, it is primary used to treat different types of nerve pain.
Ranitidine (and the brand name Zantac) is an H2 blocker. It reduces the production of stomach acid. It is sold over-the-counter and is used to treat heart burn and can help heal or prevent ulcers. Remember, long-term use is associated with Vitamin B12 deficiency.
There is no major drug interaction between gabapentin and ranitidine. Gabapentin should not be taken with antacids. Ranitidine is not an antacid, it is a acid reducer. Antacids (like Tums, Rolaids and Mylanta) can reduce the absorption of gabapentin into the body, thereby reducing the effectiveness of gabapentin. Zantac has a different action by blocking the H2 receptor and in turn reducing the amount of acid the stomach produces.
I understand it is sometimes tricky to know if a medication is an antacid or acid reducer. They sound like they could be the same thing. Antacids neutralize acid right away and acid reducers cause a reduction in the production of stomach acid. Please clarify with your pharmacist or doctor if you are unsure.