Is there and interaction between allopurinol and Indocin [indomethacin]?
Indocin (and the generic indomethacin) is a NSAID or non steroidal anti inflammatory drug. It is use to treat pain and inflammation associated with gout, arthritis and joint inflammation. Common side effects can include nausea, fluid retention, ringing in the ears and dizziness. The medication has to be used with caution in people with a history of stomach bleeding and ulcers, it can also increase the risk of heart attack and stroke.
Allopurinol is a medication that reduces the production of uric acid in the body. It is a Xanthine Oxidase inhibitor or is used to prevent gout, prevent certain types of kidney stones and treat the side effects of certain cancer treatments. The most common side effects include nausea, rash and diarrhea. Notify your healthcare providers if side effects occur, especially a rash.
There is no major interaction that has been identified between allopurinol and Indocin. In fact, indomethacin is commonly used to treat gout flares. Long-term use of NSAIDs are associated with many potential side effects and adverse reactions. Short-term use, however, tends to be tolerated much better. Always be alert for side effects and contact your doctor or pharmacist if you feel you may be having problems with your medications.