Metformin Mechanism of Action

Diabetes Medications

What is the mechanism of action of metformin?  How does metformin work in the body?

Metformin is the most common medication  of the biguanide group.  This group of medications reduce blood glucose levels in a couple of ways.  It causes a reduction in the glucose produced by the liver and kidneys.  It increase the uptake and breakdown of glucose by tissues in the body.  It slows the absorption of glucose from the colon and it seems to improve insulin sensitivity.

The nice part of increasing insulin sensitivity is that metformin is often associated with weight loss in overweight type two diabetes.  It also seems to increase fertility in women with polycystic ovary disease(pcod) – which appears to be related to insulin resistance.

Diarrhea is one of the most common side effects, but can usually be managed.  Splitting doses up, taking with food and using the extended release form of the medication may help in finding the correct metformin dosage for you.

Talk to your doctor if you think metformin is right for you.  Be sure to contact a health care provider if you need a dose change or think you may be experiencing side effects.

Don’t forget diet and lifestyle can have a huge effect on blood sugar.  There has been a lot of recent buzz on the use of resistant starch as a supplement to improve blood glucose levels as well.  High blood sugar can be detrimental to many functions  in the body and put you at increased risk of many diseases – do your best to keep it under control.

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The pharmaceutical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education and should not be used as a substitute for professional diagnosis and treatment.
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